An overview based on the meeting has been published:
Hartung T, FitzGerald RE, Jennings P, Mirams GR, Peitsch MC, Rostami-Hodjegan A, Shah I, Wilks MF, Sturla SJ. Systems Toxicology: Real World Applications and Opportunities. Chem Res Toxicol. 2017 Apr 17;30(4):870-882.
Speakers in order of appearance (click link for presentation pdf):
- Thomas Hartung, Bloomberg School of Public Health, Johns Hopkins, and Center for Alternatives to Animal Testing (CAAT), USA
"From exposure to population impact"
- Amin Rostami-Hodjegan, Systems Pharmacology, Manchester Pharmacy School, UK
"Characterizing and quantifying exposures. DMPK models for toxicant exposure"
- Marcel Leist, Center for Alternatives to Animal Testing in Europe (CAAT-Europe) and University of Konstanz, Germany
"Systems toxicology to link epidemiological data, biomarkers and risk assessment"
- Julia Hoeng, Philip Morris International R&D, Switzerland
"Building computable and mathematical models of biological networks and pathways of toxicity"
- Russell Thomas, US EPA, USA
"Reliable model systems to measure key events"
- Bob van de Water, University of Leiden, The Netherlands
"Reporter gene assays to look at system dynamics"
- Gary Mirams, University of Oxford, UK
"Computational models of cardiac electrophysiology for pro-arrhythmic safety testing"
- Sanja Asendorf, Thermo Fisher Scientific, Germany
"Analytical methods for elemental toxicant testing"
- Jenny Sandström von Tobel, SCAHT & University of Lausanne, Switzerland
"Targeted- and untargeted analysis of maturation dependent adverse effects of paraquat exposure in 3D rat brain cell cultures" (outstanding poster)
- Alice Limonciel, University of Innsbruck, Austria
"Quantifying molecular stress responses in renal cell cultures for mechanism-based chemical risk assessment" (outstanding poster)
- Christopher Portier, Switzerland
"Integrative analysis of omics measurements in systems toxicology"
- John Colbourne, School of Biosciences, University of Birmingham, UK
"Large-scale omics data generation and analysis to study population-level responses to environmental challenges"
- Martin Hofmann-Apitius, Fraunhofer SCAI, Germany
"Biological Expression Language (BEL) to express causal relationships in Systems Toxicology including Ontologies"
- Aldert Piersma, RIVM, The Netherlands
"Integrative analysis of omics data in predictive developmental toxicity"
- Albert Braeuning, Federal Institute for Risk Assessment, Berlin, Germany
"Signal integration by the CYP1A1 promoter – a quantitative study" (outstanding poster)
- Heeju Noh, ETH Zurich, Switzerland
"Inferring targets of compounds from gene transcriptional profiles" (outstanding poster)
Anja Wilmes, University of Innsbruck, Austria
"Integrative omic analysis of the nephrotoxins cisplatin and cyclosporine A in human proximal tubular cells" (best poster)
- Rebecca Clewell, ScitoVation, LLC, USA
"Linking network perturbations to phenotypes"
- Paul Jennings, Medical University of Innsbruck, Austria
"Systems toxicology: Application of integrated transcriptomic, proteomic, metabolomic and biokinetic data for understanding chemical induced renal injury"
- Ignacio Gonzalez Suarez, Philip Morris International R&D, Switzerland
"Integrating multi-omics and High Content Screening data to link biological network perturbations with cellular phenotypes to elucidate pathways of toxicity"
- Tewes Tralau, German Federal Institute for Risk Assessment (BfR), Germany
"Emerging applications for systems toxicology - aspects and challenges for regulatory toxicology"
- Joanna Jaworska, Procter & Gamble, Belgium
"Bayesian Integrated Testing Strategy (ITS) for skin sensitization potency assessment"
- Thomas Knudsen, US EPA, USA
"Embryo and fetal modeling"
You can download the meeting programme and abstracts here.